Dr. Wei Jie Teo

Prof. Marcos G. Suero

Carbyne transfer catalysis for C(sp2)–C(sp2) bond (radio)fluorinations

Wei Jie was an undergraduate at the Nanyang Technological University and started his PhD in July 2015 after working with Prof. Andy Hor and Dr. Zhao Jin in the National University of Singapore (NUS) as a research assistant. Wei Jie obtained his PhD from NUS under the supervision of Dr. Ge Shaozhong before he started in the group in October 2020.

From 01/08/2021 to



This proposal aims to develop a new C–F bond-forming strategy that exploits C–C double bonds as functional groups by means of carbyne transfer catalysis. We want to develop a general and functional group tolerant process that can use petrochemical feedstocks, fine chemicals as well as complex molecules containing alkene functionalities. The new reaction introduce asymmetry within the skeletal structure of the olefin and reach valuable secondary and tertiary allylic fluorides that are difficult or not possible to make by current methodologies based on nucleophilic fluorination. The background and leadership of the Experience Researcher (ER) are key to successfully develop the proposed project and will allow the ER and the Host group to develop a new fluorination reaction that has the potential to have broad impact in the synthesis of fluorinated bioactive molecules. A key strength of this proposal is the introduction of a secondment in the Centre for Cooperative Research in Biomaterials (CICbiomaGUNE) to develop radiolabeling studies with nucleophilic [18F]-fluoride sources. With the development of this project, the ER will acquire new scientific training in carbyne transfer catalysis, C–C bond cleavage and (radio)fluorinations, strength leadership skills by co-supervising a PhD student and to introduce the Host group into radiolabeling techniques to impact PET imaging. The host group and ICIQ have the full commitment to aid the fellow to reach a position as independent academic.

This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement 101028657

Catalytic Alkene Skeletal Modification for the Construction of Fluorinated Tertiary Stereocenters
Liyin Jiang, Pau Sarró, Wei Jie Teo, Jordi Llop, Marcos G. Suero
Chem. Sci. 2022, 13, 15, 4327-4333
DOI: https://doi.org/10.1039/D2SC00968D