Dr. Beatrice Ranieri

Prof. Antonio M. Echavarren

From gold to silver: streamlining metal-catalysed cross-coupling reactions

From 01/04/2015 to



Silvercatpharma project aims at developing C-C cross-coupling reactions catalysed by d11-blocks metals, particularly silver,
for the synthesis of pharmaceuticals in Novartis. It strives to have an impact in terms of cost, environment and international
visibility because of the use of silver as an alternative catalyst. The project offers me a great opportunity to obtain further
training, such as clusters preparation, computational and flow chemistry, and to define my final career in academia or
industry because of the possibility of working in these two different environments.

This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement 658256

Enantioselective Synthesis of Cyclobutenes by Intermolecular [2+2] Cycloaddition with Non-C2 Symmetric Digold Catalysts
C. García-Morales, B. Ranieri, I. Escofet, L. López-Suárez, C. Obradors, A.I. Konovalov, A.M. Echavarren
J. Am. Chem. Soc. 2017, 139, 13628-13631
DOI: 10.1021/jacs.7b07651

α,β-Unsaturated Gold(I) Carbenes by Tandem Cyclization and 1,5-Alkoxy Migration of 1,6-Enynes: Mechanisms and Applications
P. Calleja; O. Pablo; B. Ranieri, M. Gaydou, A. Pitaval, M. Moreno, M. Raducan, A.M. Echavarren
Chemistry-A European Journal 2016, 22, 13613-13618.
DOI: 10.1002/chem.201602347

Synthesis of Rumphellaone A and Hushinone by a Gold-Catalyzed [2+2] Cycloaddition
B. Ranieri, C. Obradors, M. Mato, A. M. Echavarren
Org. Lett. 2016, 18, 1614-1617
DOI: 10.1021/acs.orglett.6b00473

Anatomy of gold catalysts: facts and myths
B. Ranieri, I. Escofet, A. M. Echavarren
Org. Biomol. Chem. 2015, 13, 7103-7118
DOI: 10.1039/C5OB00736D