GASGOLD aims for the development of efficient Au(I)-catalysed methodologies for the challenging intermolecular synthesis
of important monomers, oligomers and polymers of acetylene gas. Au(I)-catalysts allow for the formation of cyclopropyl
Au(I)-carbenes after reaction with an alkyne and alkene. The carbenes are reactive towards rearrangement to form 1,3-
dienes, which are important building blocks for a range of natural and other important products, such as synthetic rubbers.
Preliminary results show that further reaction of certain 1,3-dienes with acetylene can occur, forming oligomeric derivatives
and this reactivity will be harnessed and further exploited in this project. Initially, the development of an effective protocol for
the synthesis of a wider range and more challenging substituted 1,3-dienes from acetylene gas, both in monomeric and
oligomeric forms, will be established. The reaction mechanism determining the configuration of the alkenes will be studied,
for example by kinetic monitoring and isolation of reaction intermediates, to explain the observed selectivity, potentially
synthesise other isomers and improve on the reaction conditions and catalyst design. The initial results will inspire the
challenging selective expansion of 1,3-dienes with acetylene to form substituted 1,3,5-hexatrienes. Additionally, the
unprecedented use of both acetylene and ethylene gas in Au(I)-catalysis will be explored for the synthesis of polyacetylene
derivatives, which are highly important materials with electrical conductivity, as well as in the purification of ethylene gas.
The development of this project offers an innovative solution for the long-standing problem of utilising acetylene gas as a
simple building block in Au(I)-catalysis, offering a clear advantage over the current state-of-the-art of the field. Furthermore,
the expected synergistic performance between the experienced researcher and the host group, will maximise the potential
for success of the project.
This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement 101029012